Metformin attenuates hyperglycaemia-stimulated pro-fibrotic gene expression in adventitial fibroblasts via inhibition of discoidin domain receptor 2

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  • who: Allen Sam Titus et al. from the of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical and Technology, Trivandrum, Kerala, India Department of Biotechnology, University of Kerala, Kariavattom, Trivandrum, Kerala, India have published the research work: Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2, in the Journal: (JOURNAL)
  • what: Using gene knockdown and overexpression approaches this study examined whether DDR2 is a target of and whether by targeting DDR2 it inhibits and expression in rat aortic adventitial fibroblasts exposed to hyperglycaemic conditions . . .

     

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