Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in app/ps1 mice

HIGHLIGHTS

• who: Yanxing Chen from the Medicine, Zhejiang University, Hangzhou, People’s Republic of China have published the research: Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice, in the Journal: (JOURNAL)
• what: The authors seeded APP/PS1 mice with tau seeds to investigate the effects of amyloid pathology on tau seeding activity. The study showed that metformin limited the propagation of Aβ and NP tau pathology in APP/PS1 mice.
• how: The results showed that injection of proteopathic tau seeds decreased plaque-associated microgliosis.
• future: Studies . . .
  

   

  

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