Metformin, rapamycin, or nicotinamide mononucleotide pretreatment attenuate cognitive impairment after cerebral hypoperfusion by inhibiting microglial phagocytosis

HIGHLIGHTS

  • who: Qichuan Zhuge and Kunlin Jin from the University of Florida, United States have published the research work: Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis, in the Journal: (JOURNAL)
  • what: The authors used bilateral common carotid artery occlusion (BCCAO), which is widely accepted as an experimental model of VCI , to examine the effects of the anti-aging drugs on the outcomes after surgery.
  • how: The data showed that long-term metformin rapamycin or NMN pretreatment significantly ameliorated BCCAO-induced WMLs and profoundly facilitated cognitive . . .

     

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