HIGHLIGHTS
- who: Elisabet Cuyà from the Oncology, Girona, Spain University of Minho, Portugal have published the Article: Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology, in the Journal: (JOURNAL)
SUMMARY
The targeting of core "hub" metabolites with epigenetic properties, such as SAM and SAH, supports the notion that metformin can activate epigenetic cancer-protection programs by promoting genome-wide DNA methylation events including methylation-regulated motility of retrotransposable_elements such as long interspersed nuclear element-1 (LINE-1) or hypermethylation of tumor-promoting pathway genes. Metabolic adaptation to calorie restriction, fasting, the intake . . .
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