Methamphetamine signals transcription of il1 and tnf in a reactive oxygen species-dependent manner and interacts with hiv-1 tat to decrease anti-oxidant defense mechanisms

HIGHLIGHTS

  • who: Liana V. Basova1 and collaborators from the Tulane University, United States have published the paper: Methamphetamine signals transcription of IL1 and TNF in a reactive oxygen species-dependent manner and interacts with HIV-1 Tat to decrease anti-oxidant defense mechanisms, in the Journal: (JOURNAL)
  • what: In subsequent assays, the authors focused on lower doses of Tat that are more physiologically relevant. In the analysis, the authors focused on gene promoter intervals that showed increased RNAPol recruitment by Meth, but that was prevented by the addition of NAC treatment, to distinguish pro-transcriptional Frontiers . . .

     

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