Methiothepin increases chemotherapy efficacy against resistant melanoma cells

HIGHLIGHTS

• who: Nelly Durand and collaborators from the Université Côte d'Azur, CNRS, IPMC, France, Institut de Pharmacologie Moléculaire et Cellulaire have published the research work: Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells, in the Journal: Molecules 2021, 1867 of /2021/
• what: The authors show that also inhibits doxorubicin efflux and increases doxorubicin cytotoxicity in melanoma cells which endogenously overexpress Melanoma patients having the BRAFV600E mutation are treated with vemurafenib an inhibitor of BRAFV600E often in combination with trametinib an inhibitor of MEK. The authors show that methiothepin enhances the efficacy of doxorubicin . . .
  

   

  

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