Method for detecting acetylated pd-l1 in cell lysates by immunoprecipitation and western blot analysis

HIGHLIGHTS

• who: Frances Middleton-Davis et al. from the (UNIVERSITY) have published the Article: Method for detecting acetylated PD-L1 in cell lysates by immunoprecipitation and western blot analysis, in the Journal: PLOS ONE of July/18,/2022
• what: As validation the authors demonstrate that acetylation levels increase to 0.11-0.17% of total PD-L1 after a 4h treatment with the histone deacetylase (HDAC) inhibitor trichostatin A (TSA). In this regard, acetylation of the relatively unstructured cytoplasmic tail of PD-L1, which contains five potential acetylation sites, is a major focus of current research . . .
  

   

  

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