HIGHLIGHTS
SUMMARY
Although many drugs have proven to be neuroprotective in preclinical studies, most of them have failed in clinical trials (Gaire, 2018; Campbell et_al, 2019). It has been suggested that TCM may improve cerebral microcirculation in the brain (Gong and Sucher, 1999), protect against ischemic reperfusion injury (Lee et_al, 2005; Wang et_al, 2005), reduce oxidative stress reaction (Bi et_al, 2012), possess neuroprotective properties, and inhibit apoptosis (Kim, 2005). High-quality systematic reviews/meta-analyses can provide a more valuable reference for clinical practices than individual studies (Schalken and Rietbergen, 2017; Vrieze, 2018); however, some studies . . .
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