Methotrexate inhibits t cell proliferation but not inflammatory cytokine expression to modulate immunity in people living with hiv

HIGHLIGHTS

• who: Michael L. Freeman from the Midwestern University, United States have published the paper: Methotrexate Inhibits T Cell Proliferation but Not Inflammatory Cytokine Expression to Modulate Immunity in People Living With HIV, in the Journal: (JOURNAL)
• what: The authors propose that cellular progression to cell division after cell cycle entry in the absence of Bcl-2 and in the presence of MTX (and thus, the absence of DHFR activity) results in their demise.
• how: The data are consistent with the interpretation that MTX impairs activation-induced T_cell proliferation via inhibition of DHFR and . . .
  

   

  

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