HIGHLIGHTS
- who: Nan Su from the of China Medical University (#AF-SOP-07-10-01) have published the Article: Methylation of SPRED1: A New Target in Acute Myeloid Leukemia, in the Journal: (JOURNAL)
- what: One of the main reasons is that little is known about the targets of demethylating agents themselves, and the specific genes that are hypermethylated drive the leukemogenesis. In this study, the prognostic impact of abnormal SPRED1 methylation on AML was assessed in a large cohort of patients. The study demonstrates that in AMLs, SPRED1 is hypermethylated, and de-hypermethylation of SPRED1 could . . .
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