HIGHLIGHTS
SUMMARY
It remains unclear if nuclear METTL3 is functionally distinct from cytosolic METTL3 in driving tumorigenesis and, if any, how tumor cells sense oncogenic insults to coordinate METTL3 functions within these intracellular compartments. When the authors grouped these clinical samples into nonmetastases (n=160) and metastases (n=131) based on lymph node status, approximately 75% of non-metastases samples (120/160) had strong cytoplasmic staining of METTL3 but lacked METTL3 expression in the nucleus ( and amp;lt;10% of counted cells showing positive nuclear staining of METTL3) (Fig 1c). Collectively, these data indicate a potential . . .
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