Mettl4-mediated nuclear n6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets

HIGHLIGHTS

  • who: Kai-Wen Hsu from the Taoyuan, Taiwan have published the research work: METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets, in the Journal: (JOURNAL)
  • what: The authors show that induces 6mA modification through a DNA methyltransferase in hypoxia-induced epithelial-mesenchymal transition (EMT) and tumor Co-expression of and 6mA represents a prognosis marker for upper tract urothelial cancer patients. The authors demonstrate that is an essential co-activator of HIF-1u03b1. The authors show that results in enriched 6mA levels in mammalian tumor cells through This METTL4 . . .

     

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