HIGHLIGHTS
- who: TYPE et al. from the Medical Center, United States have published the research work: MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites, in the Journal: (JOURNAL)
- what: The authors demonstrate that the MAM protein MFN2 is involved in the formation of MAMs with a long lifetime during ER stress.
SUMMARY
The discovery of ER and mitochondrial contact sites (Rizzuto et_al, 1998) led to the discovery that mitochondrial-associated ER membranes (MAMs) serve as Ca2+ hotspots (Giacomello et_al, 2010) facilitating the Ca2+ flow from the ER . . .
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