HIGHLIGHTS
- who: Major histocompatibility complex et al. from the Hospital Israelita Albert Einstein, São Paulo, SP, Brazil have published the article: MHC structure and function − antigen presentation. Part 2, in the Journal: (JOURNAL)
SUMMARY
A central role for MHC in the immune_response to protein antigens was suggested in the 1970 when experimental evidence showed that T lymphocytes recognize portions of antigens (peptides) only when bound non-covalently to products of the HLA genes. HLAI and HLAII molecules transport peptides produced in different cellular compartments (proteasomes and endosomes, respectively), in which different proteolysis strategies . . .
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