Mib1 prevents notch cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination

HIGHLIGHTS

• who: Chooyoung Baek et al. from the 6, IFD, Paris, France, The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of have published the paper: Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination, in the Journal: (JOURNAL) of March/29,/2018
• what: The authors show that Notch signaling which is classically associated with an undifferentiated state remains active in prospective neurons until they delaminate. The authors propose that the fine-tuned balance between Notch Trans-activation and Cis-inhibition allows neuroepithelial cells to seamlessly delaminate . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.