Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines

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SUMMARY

Morphological analysis revealed significantly reduced spine density in ­NT-/- mice. ­NT-/- mice have shown a lower proportion of thin/filopodialike spines, in line with the hypothesis that NT may specifically affect filopodia formation. As NT is expressed in the hippocampus, the authors tested spaced LTP in ­NT+/+ and N ­ T-/- juvenile mice at CA3-CA1 synapses (Fig 1A). To test whether impaired context discrimination was due to impaired visual function in N ­ T-/- mice, the authors subjected these mice to the novel object recognition test (NORT) that critically depends on visual discrimination. Age‑persistent . . .

 



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