Mice with deficiency in pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature

HIGHLIGHTS

• What: The authors evaluated the behavioral phenotype of Pcdh15deletion mice to establish face validity, ensuring the appropriateness of the model for investigating the mechanisms linking Pcdh15 deletion to psychiatric disorders such as BD. Rather than mimicking specific patients, the authors aimed to focus on exons encoding a greater number of proteins reported in the database, and aimed to nullify PCDH15.
• Who: Daisuke Mori from the Animal experiments All research and animal care procedures were ethically approved by the Nagoya University Animal Care and Use CommitteeMice were housed in groups of up to six animals per . . .
  

   

  

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