Mice with lung airway ciliopathy develop persistent mycobacterium abscessus lung infection and have a proinflammatory lung phenotype associated with decreased t regulatory cells

HIGHLIGHTS

• who: Audrey Nava and collaborators from the Italy Washington University in StLouis have published the article: Mice with lung airway ciliopathy develop persistent Mycobacterium abscessus lung infection and have a proinflammatory lung phenotype associated with decreased T regulatory cells, in the Journal: (JOURNAL)
• what: The authors show that Mabs introduced into the lungs of mice as a low inoculum embedded in agarose beads persists for a prolonged period (at least 8 weeks) in mice that have lost IFT88 (IFT88 KO mice), while control mice clear lung infection. Consistent with this data, the authors show that . . .
  

   

  

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