HIGHLIGHTS
- who: Boncel et al. from the Silesian University of, Department of Organic Chemistry have published the research work: Michael-type addition of azoles of broad-scale acidity to methyl acrylate, in the Journal: (JOURNAL)
- what: We have developed and optimised a simple and effective synthetic protocol for Michael-type addition of azoles of broadscale acidity including pyrazole, imidazole and 1,2,4-triazole derivatives.
SUMMARY
1,2-Arylimidazole derivatives, e_g, 2-(3-chloro-4-methylphenyl)-1-phenyl-4-(trifluoro-methyl)imidazole (I) are selective cyclooxygenase (COX-2) inhibitors. The base-catalysed . . .
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