Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy

HIGHLIGHTS

• who: Ashraf S.A. El-Sayed from the Department, Faculty of Science, Zagazig University, Egypt have published the article: Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy, in the Journal: (JOURNAL)

SUMMARY

Cytosine deaminase (CDA) (E.C 3.5.4.1) is an amidohydrolase that catalyzes the deamination of cytosine into uracil and ammonia (Kilstrup et_al, 1989; Danielsen et_al, 1992; Mullen, 1994; Mullen et_al, 1994). CDA has been distributed in microorganisms with potentiality to convert the non-toxic 5-fluorocytosine (5-FC) into toxic . . .

 



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