HIGHLIGHTS
- who: Intestinal epithelial HDAC et al. from the Divisionand the University of of Medicine, Cincinnati, Ohio, USA have published the article: microbiota-specific immunity, in the Journal: (JOURNAL)
- what: While ILC3s are relatively rare cells at the luminal surface of the intestine, the authors show that IECs are a major source of intestinal MHCII.
- future: Analysis of tissues from mice reared under germ-free conditions demonstrated that HDAC3 was necessary for microbiota to induce epithelial MHCII-dependent regulation of microbiotaspecific CD4+ T_cells.
SUMMARY
Commensal bacteria drive regulatory T_cell differentiation . . .
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