Microglial pten safeguards postnatal integrity of the cortex and sociability

HIGHLIGHTS

  • who: Xing Zhou et al. from the Chengdu of Traditional Chinese Medicine, China have published the Article: Microglial Pten safeguards postnatal integrity of the cortex and sociability, in the Journal: (JOURNAL)
  • what: The study demonstrates that microglia-specific Pten deletion, when induced immediately after birth but not after two weeks, causes profound defects in neuronal development and functions, leading to abnormal social behaviors later in life.
  • how: All animal experiments were conducted in accordance of government and Tsinghua guidelines for animal welfare and approved by Tsinghua Institution Animal Care and Use Committee. For . . .

     

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