HIGHLIGHTS
SUMMARY
Proliferative vitreoretinopathy (PVR) indicates an abnormal intraocular scarring process that complicates up to 10% of cases of rhegmatogenous retinal detachment (RRD), characterized by the formation of epiretinal and/or subretinal fibrotic cell membranes and intraretinal fibrosis, capable of contracting, generating a tractional retinal detachment or a mixed retinal detachment in case of the formation of new retinal breaks. Epithelial-Mesenchymal Transition (EMT) can be activated in pathological circumstances, such as inflammation, wound healing and carcinogenesis, allowing epithelial_cells to achieve greater migration capacity and to increase their production of extracellular matrix components. The authors focused . . .
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