Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

HIGHLIGHTS

• who: Chris Greene from the Smurfit InstituteUniversity of have published the Article: Microvascular stabilization via blood-brain barrier regulation prevents seizure activity, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show for the first time, a direct correlation between human epilepsy and claudin-5 levels at the BBB. Using a range of advanced imaging paradigms in human subjects coupled to 4 distinct animal models, the authors show that focal and brain-wide depletion of claudin-5 results in seizures in mice. The authors show that restoration of claudin-5 levels attenuates seizures and . . .
  

   

  

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