Midkine inhibition enhances anti-pd-1 immunotherapy in sorafenib-treated hepatocellular carcinoma via preventing immunosuppressive mdscs infiltration

HIGHLIGHTS

• who: Lijuan Ding from the Patient samples The collection and use of human samples were approved by the Ethics Committee of the First Hospital of Jilin UniversityThe study was performed according to the guidelines with the Declaration of Helsinki and Ethics Committee of the First Hospital of Jilin University. Informed consents were obtained from all enrolled participants. Four pairs of HCC specimens and adjacent normal tissues were collected from the First Hospital of Jilin University between March , and June, . Ten blood samples from healthy donors were collected, then peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll . . .
  

   

  

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