HIGHLIGHTS
- who: Tian Xia from the (UNIVERSITY) have published the Article: Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex, in the Journal: (JOURNAL) of 23/03/2022
- what: The authors report that intracellular MDK suppresses AMPK activation by interacting with LKB1 and STRAD to depolymerize the LKB1-STRAD-Mo25 complex and reduce LKB1 activity, consequently decreasing the phosphorylation of AMPKu03b1.
- how: This result indicated that the interaction between MDK and AMPK may be dependent on LKB1. These results indicated that LKB1 is involved in the MDK-induced regulation of AMPK . . .
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