HIGHLIGHTS
- who: Min Zhao from the Sorbonne University Lausanne, Lausanne, Switzerland have published the Article: Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that spironolactone, an oral MRA may reduce signs of CNV activity in nAMD patients with resistant active CNV despite monthly intraocular anti-VEGF injections. Using both pharmacologic and transgenic approaches in rodents, the authors show that antagonism of the mineralocorticoid pathway prevents CNV through a VEGF-independent mechanism. The authors demonstrated that MR . . .
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