HIGHLIGHTS
- who: Zachary M. Howard and collaborators from the DepartmentState University, Columbus, Ohio, USA have published the research: Mineralocorticoid receptor antagonists pathology in muscular dystrophy, in the Journal: (JOURNAL)
- future: Since prednisolone and spironolactone compete for GR and MR binding and reduce the efficacy of each other and since GR agonism and MR antagonism lead to similar overall antiinflammatory changes alternating administration of the 2 drugs could be investigated for improved efficacy in future studies.
SUMMARY
Chronic inflammation exacerbates skeletal muscle pathology in Duchenne muscular dystrophy (DMD) and will likely persist even . . .
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