Mir-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (bmscs) isolated from osteoporotic sam/p6 mice

HIGHLIGHTS

• who: Mateusz Sikora from the SAM/, mice strain (senescence-accelerated mice prone, ) was used as an animal model of senile osteoporosisThe strain belongs to SAM group of inbred mouse strains that are used as animal models of senescence acceleration, as well as age-related disorders. The SAM/ , strain was obtained by Dr. Takeda during brother-sister mating of AKR/J mice in Kyoto University. In the age of , months, SAM/, mice presents the full spectrum of senile osteoporosis symptoms: low global bone density, deteriorated osteogenesis of bone marrow, deficits in endocortical mineralizing surface, reduction of BMD index . . .
  

   

  

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