Mir-24 regulates intrinsic apoptosis pathway in mouse cardiomyocytes

HIGHLIGHTS

  • who: Cardiomyocytes and colleagues from the Department of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine have published the Article: miR-24 Regulates Intrinsic Apoptosis Pathway in Mouse Cardiomyocytes, in the Journal: PLOS ONE | www.plosone.org of January/15,/2014
  • what: The authors demonstrated that Bim and its interacting partners, such as CHOP and Bax, are the major downstream mediators of miR-24 in inhibiting cardiomyocyte apoptosis.
  • how: The authors showed that miR-24 modulated intrinsic apoptosis by interacting with CHOP-mediated ER pathways and by inhibiting cytochrome C release . . .

     

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