Missense mutation of fmr1 results in impaired ampar-mediated plasticity and socio-cognitive deficits in mice

HIGHLIGHTS

• who: Marta Prieto from the CNRS RomaTre University, DeptScience, Rome, Italy. have published the Article: Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that Fmr1R138Q mice exhibit postsynaptic alterations in the hippocampus, including an increased dendritic spine density, AMPAR-mediated synaptic plasticity defects associated with severe impairments in their socio-cognitive performances.
• future: This may also lead in the near future to the development of clinical studies to assess the potential benefits of these . . .
  

   

  

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