Missing self triggers nk cell-mediated chronic vascular rejection of solid organ transplants

HIGHLIGHTS

• who: Alice Koenig from the CNRS Bernard University have published the research work: Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: This mimics the "missing self" for NK cells, and the authors show that this is sufficient to provoke EC damage in_vitro and in_vivo. To determine how these distinct signals contribute to cell activation, the authors focused the analysis on NK cells that expressed two inhibitory KIRs, one being responsible for missing selfinduced activation. Based on previous work from the group41 ,42 . . .
  

   

  

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