HIGHLIGHTS
- who: Jae-Sung Kim and colleagues from the Department of Surgery, Washington University in StLouis, StLouis, MO, USA have published the research work: Mitochondrial Autophagy in Ischemic Aged Livers, in the Journal: Cells 2022, 11, 4083. of /2022/
- what: __SECTION__ 4. Conclusions and Future Perspectives.
- how: Impaired or insufficient autophagy thus results in hepatocyte death after I/R. This review describes the current understanding of the effects of aging on I/R injury in hepatocytes and highlights the mechanistic correlation of autophagy with the pathogenesis of age-dependent hypersensitivity to reperfusion injury.
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