Mitochondrial creatine kinase 1 regulates the cell cycle in non-small cell lung cancer via activation of cyclin-dependent kinase 4

HIGHLIGHTS

• who: Mengjie Yang from the Animal experiments were approved by the Sun Yat-sen University Cancer Center Institutional Animal Care and Usage CommitteeFemale BALB/c nude mice (4, weeks old, g) were purchased from the SLRC laboratory Animal Co. (Shanghai, China). Mice were used to generate xenograft models via subcutaneous transplant of tumor sections (approximately , m u00ad m3) from lung cancer cell xenografts into the right flank. For Dox-dependent tumor experiments, mice were fed with Dox-containing sugar water, days after tumor transplantations. The volume and weight of tumors were monitored and evaluated. The tumor volume . . .
  

   

  

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