HIGHLIGHTS
- who: Yue Guo from the Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China have published the research work: Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells, in the Journal: (JOURNAL)
- what: The authors investigated the involvement of cytosolic mtDNA in noninfectious immune in RMECs under pathological stimuli. The authors have shown that pathogenic stimulation causes MPTP opening and the escape of mtDNA, which was detected with immunofluorescence.
- how: Given the importance of mtDNA-cGAS signaling in inflammation the authors examined its . . .
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