Mitochondrial dysfunction reveals the role of mrna poly(a) tail regulation in oculopharyngeal muscular dystrophy pathogenesis

HIGHLIGHTS

• who: Aymeric Chartier et al. from the Editor:, Stanford University School of Royal Holloway, University of London, Egham, Surrey, United Kingdom have published the research: Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis, in the Journal: (JOURNAL) of March/27,/2015
• what: The authors show using Drosophila and mouse models that OPMD depends on affected poly(A) tail lengths of specific mRNAs. The authors focus on the deadenylation regulator Smaug and show that it is expressed in adult muscles and specifically binds to the down-regulated mRNAs . . .
  

   

  

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