HIGHLIGHTS
- who: Xinyuan Lei from the Memorial Hospital of Sen University, Boston, MA, USA have published the paper: Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: This study proposes a model whereby mitochondrial fission contributes to cancer cell immunoescape, providing attractive targets for clinical therapeutics.
- how: To further investigate the clinical relevance of the findings the authors explored whether Mdivi-1 could arouse the immune dormancy and improve ACT effects in cancer patient-derived xenograft (PDX) model implanted in immunocompromised NOD . . .
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