Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase*

HIGHLIGHTS

• who: Paul A. Cobine from the Paul ACobine, Fabien Pierrel, Megan L. Bestwick, and Dennis R. Winge, From the University of Utah Health Sciences Center, Departments of Medicine and Biochemistry, Salt Lake City, Utah , A mitochondrial matrix copper ligand (CuL) complex, conserved in mammalian cells, is the likely source of copper for assembly of cytochrome c oxidase (CcO) and superoxide dismutase , (Sod1) within the intermembrane space (IMS) in yeast. Targeting the copper-binding proteins human Sod, and Crs, to the mitochondrial matrix results in growth impairment on nonfermentable medium caused by decreased levels of CcO. This effect . . .
  

   

  

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