Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by parkin and pink1

HIGHLIGHTS

• who: L F Burbulla from the German Center forUniversity of Tübingen, Tübingen, Germany have published the research work: Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1, in the Journal: (JOURNAL)
• what: Collectively, the authors provide first insights into the role of the intramitochondrial protein quality_control in PD and integrate mortalin defects into molecular pathways related to PINK1/ Parkin-mediated organellar homeostasis in PD pathogenesis. The authors propose a linear signaling cascade in which loss of mortalin triggers impaired mitochondrial proteostasis that is upstream of PD-related . . .
  

   

  

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