HIGHLIGHTS
- who: Sylvain Delaunay from the (UNIVERSITY) have published the Article: Mitochondrial RNA modifications shape metabolic plasticity in metastasis, in the Journal: (JOURNAL) of 27/Oct/2020
- what: The authors show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications- 5-methylcytosine (m5C) and its derivative 5-formylcytosine (f5C) (refs.2-4)-drive the translation of mitochondrial mRNA to power metastasis. The authors show that mitochondrial cytosine-5 RNA methylation is essential for the dynamic regulation of mitochondrial translation rates, and thereby shapes metabolic reprogramming during metastasis. The authors show that the CD44- and . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.