HIGHLIGHTS
- who: COPYRIGHT et al. from the National University of, (VIMM), Italy have published the paper: Mitochondrial sirtuin 3 and various cell death modalities, in the Journal: (JOURNAL)
- what: Interestingly, in this study, Sirt3 was shown to directly deacetylate another inflammasome component, NLR domain-containing protein 4 (NLRC4), to promote pyroptosis (Guan et_al, 2021). p53-mediated ferroptosis, protecting human cancer cells from the stress caused by ROS accumulation (Jin et_al, 2021).
SUMMARY
Suppression of Sirt3 expression in breast cancer cells, and the subsequently elevated ROS production, makes these cells more susceptible to . . .
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