Mitochondrial trxr2 regulates metabolism and protects from metabolic disease through enhanced tca and etc function

HIGHLIGHTS

• who: E. Sandra Chocron from the Mouse modelWe generated a CAG-Lp-STOP-Lp-Trx, construct which was microinjected by the University of Michigan transgenic core. Male mice containing the transgene in a CB, /C Bl/, J background were crossed with a homozygous CRE EIIa female germline overexpressor mouse (Cat#, Jackson Labs). The EIIa-Cre mice carry a Cre transgene under the control of a zygotically expressed (EIIa-Cre) promoter that activates the expression of Cre recombinase in the early mouse embryos20. This resulted in a first-generation with, % transgene expression. We then crossed positive mice with . . .
  

   

  

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