HIGHLIGHTS
- who: Yanjie Guan from the (UNIVERSITY) have published the research work: Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics, in the Journal: (JOURNAL)
- what: With deep dissection of its role in carcinogenesis and drug resistance, mitophagy could become a breakthrough in cancer therapy.
SUMMARY
Under severe conditions, in which mitophagy cannot handle a large number of damaged or dysfunctional mitochondria, cell death pathways are activated, and mitophagy is suppressed. When knocking out the mitophagy-related gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) in mice, mitochondria accumulation . . .
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