HIGHLIGHTS
- who: Florian J. Groelly from the Department University of , DQ, UK have published the article: Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells, in the Journal: (JOURNAL) of September/15,/2022
- what: The work provides a mechanism for how tumor-predisposing inactivation links transcription-induced with repair to fuel the genomic instability characteristic of cancer cells. The authors demonstrate that MiDAS reactions were RAD52-dependent and acted to limit the genomic instability caused by BRCA2 inactivation. The work provides insights into the origins of cancer in patients carrying BRCA2 mutations . . .
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