Mitotic regulation of sirt2 by cyclin-dependent kinase 1-dependent phosphorylation*

HIGHLIGHTS

• who: Brian J. North from the Brian JNorth and Eric Verdin, From the Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California , Sirtuins are evolutionarily conserved NADⴙ-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair, genomic silencing, and longevity. Recent studies have focused on identifying target substrates for human sirtuin enzymatic activity, but little is known about processes that directly regulate their function. Here, we demonstrate that , is phosphorylated both in vitro and in vivo on serine , by the cell-cycle regulator, cyclin-dependent . . .
  

   

  

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