HIGHLIGHTS
SUMMARY
This phenomenon has been observed also in in_vitro studies on human blood and tissues, where 35 out of 100 analysed chemicals were detected, but their predicted mixture effect derived from single-compound modelling explained less than 2% of the experimental mixture effect (activation of the arylhydrocarbon receptor and cytotoxicity). The authors suggest overcoming this issue by resorting to specific in_vitro data of chemicals, where active chemicals by default can be considered to belong to the same CAG. This approach assumes that chemicals are acting additively within a mixture, that the in_vitro effect can be . . .
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