Mmp7 cleavage of amino-terminal cd95 death receptor switches signaling toward non-apoptotic pathways

HIGHLIGHTS

• who: Shoji F. Kenji from the (UNIVERSITY) have published the article: MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways, in the Journal: (JOURNAL) of 25/07/2022
• what: To evaluate this model, the authors generated a soluble K33G CD95 mutant (sCD95 K33G) and expressed it in HEK/293 T_cells (Fig 4E) to compare its stoichiometry to its wild_type counterpart using size exclusion chromatography (Fig 4G).
• how: These data indicated that the extracellular region of CD95 predominantly formed dimeric complexes (Fig 4F). Taken together these results showed that . . .
  

   

  

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