HIGHLIGHTS
- who: Katarzyna Augoff and colleagues from the Department Surgical Education, Wroclaw Medical University, Wroclaw, Poland have published the paper: MMP9: A Tough Target for Targeted Therapy for Cancer, in the Journal: Cancers 2022, 1847 of 23/02/2022
SUMMARY
Remarkable upregulation of gene_expression and the activity of MMPs, especially MMP9, has been observed in various malignancies. All these mechanisms can contribute to both the activation and repression of MMP9 gene_expression. For instance, the proximal AP-1 has been found to activate MMP9 gene_expression in synergism with NF-κB and Sp1. Also the CDKN1A . . .
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