HIGHLIGHTS
- who: Marián Merino et al. from the Biopolo Hospital La Fe, Valencia, Spain Departamento de Química Orgánica e Inorgánica, Instituto de Ciencia Molecular, Universidad de Valencia have published the research: Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington’s Disease, in the Journal: (JOURNAL)
- what: The authors show that one Mn(II) quinone (4QMn) designed to work as an artificial superoxide dismutase is able to activate both the ubiquitin-proteasome system and the autophagy pathway in vitro and in vivo models of HD. The . . .
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