Model-based intensi fi cation of cho cell cultures: one-step strategy from fed-batch to perfusion

HIGHLIGHTS

  • who: August and colleagues from the University of Minho, Portugal United Kingdom have published the research work: Model-based intensi fi cation of CHO cell cultures: One-step strategy from fed-batch to perfusion, in the Journal: (JOURNAL)
  • what: The authors focused on the development of a modeling structure enabling the description of upstream bioprocess dynamics and the transfer between operations (specifically, from fed-batch to continuous culture) at different scales (from Ambr 250 to Univessel 2L) with a single set of kinetic parameters. For analysing the uncertainty on the model outputs with respect to . . .

     

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